AMMRL: GLP/GMP NMR Questions

From: MF Leopold <mfleopold_at_yahoo.com>
Date: Wed, 14 Nov 2012 17:33:30 -0800 (PST)

Hi Everyone,
 
So my next question relates to GLP/GMP NMR.
 
At some point, I will need to run GMP samples on my "new" NMR.  I had thought that it would be best to have the instrument installed as a GLP/GMP instrument with vendor software that would run the standard tests and determine suitablity for use.  I also wanted to add the second tier of software after installation that allowed me to build libraries for specific products/raw materials (many!) and that would allow me to automate pass/fail of products.
 
If any vendor (manufacturer or third party) says he will prove complete IQ/OQ/PQ to meet 13485 as well as GLP installation - what do I look for to judge compliance to Standards (Medical Devices/Pharma) and traceability?  What sort of certification should the vendor engineer provide as part of the documentation?  Should the vendor have a Quality System in place and documented, controlled procedures to cover the installation/qualification?  Any particular Standard that covers NMR as an analytical tool that I need to read/incorporate into the installation?
 
1.  So if you are running a GLP/GMP NMR lab - how did you get started?  did you dive in and do it old school or did you rely on vendor software/help?
2.  If you could start from scratch again, what would you do differently?
3.  For comparison purposes, how many GMP product/raw material protocols do you run per instrument in your facilities (not how many samples)?
 
Hate to bother you all.  I hope that a few of you will take a little time to educate me.
 
Best regards,
MF Leopold
Life Technologies
mary.leopold_at_lifetech.com
 
Received on Wed Nov 14 2012 - 15:33:33 MST

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