Date: Tue, 27 Mar 2001 16:27:31 -0500
The XNMR product from Advanced Chemistry Development allows both the
prediction of F19 chemical shifts (and couplings) as well as searching
literature data by structure, substructure, name, chemical shift and so on.
Details can be found at www.acdlabs.com/products under the F19 NMR link.
Searching the DB by 5-fluorotryptophan gave the following references:
Biochemistry,1986,v.25,p.4240
Biochem. J.,1990,v.266,p.545
A screen capture of the DB hit is attached as a GIF file. Since the DB is
searchable you can define your own substructures for searching or simply
draw the structure to predict the shift. Best wishes
-----Original Message-----
> From: Sandip Sur [mailto:sur_at_chem.rochester.edu]
> Sent: Monday, March 26, 2001 11:38 AM
> To: Mo Latif
> Cc: ammrl_at_wwitch.unl.edu
> Subject: Re: 19F chemical shift ranges
Mo,
I like the Gunther's NMR Spectroscopy (1980, Ch 10), for a short
introduction to 19F NMR. There are 19F books I know that list 19F
Chemical shifts and Coupling constants very extensively. If you do not get
your answer soon, let me know.
Sandip
>
>
>Greetings,
>
>
>I'm working with some Fluorinated peptides, particularly incorporation of
>5-Fluorotryptophan into a 15 residue peptide and am looking for pointers
>as to where I could find a table of general regions of 19F chemical shifts
>or in particular fluorinated aromatic amino acids.
>
>
>Many thanks for any assistance you can provide.
>
>
>Mo
>
>
>
>Dr. Mohammed A. Latif
>Cubist Pharmaceuticals (UK) Ltd
>545 Ipswich Road
>Slough
>Berkshire SL1 4EQ
>England UK
>Tel: +44 (0) 1753 706 800 (switchboard)
>Tel: +44 (0) 1753 706 713 (direct dial and voice mail)
>Fax: +44 (0) 1753 706 808
><mailto:mo.latif_at_terragen.co.uk>mailto:mo.latif_at_terragen.co.uk
>www.Cubist.com
>
>
>
>
>
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*** BEST WISHES FOR 2001 ***
____________________________________________________________________________
____
Sandip K. Sur, Ph.D. Email: sur_at_chem.chem.rochester.edu (W)
Manager and Application Scientist
NMR Facility
Department of Chemistry Tel.: (716) 275 4705 (W)
B53B Hutchison Hall (716) 275 0912 (W)
River Campus (716) 586 7794 (H)
University of Rochester Pager: (716) 275-4231 (ask for me)
Rochester, NY 14627-0216 Fax: (716) 473 6889
Monday, March 26, 2001
____________________________________________________________________________
____
(image/gif attachment: 5-fluoro.gif)