We are about to upgrade our Bruker AMX-500 spectrometer to gradient
capability and I am seeking opinions on which upgrades will be the most
cost effective for our needs. We are a Marine Natural Product Chemistry
lab doing isolation/structure elucidation mainly of small molecules
(<1Kd). We are debating whether to purchase a triple axis grasp III
unit ($40,000) or if we can get by with the single axis Grasp II
($17,000). Most of the standard experiments that we do only require
single axis (COSY, TOCSY, HMQC-TOCSY, HMBC, etc.). What particular
advantages would the triple axis capability have for small molecules and
would it be worth the cost difference? Do any of these experiments run
better with triple axis gradients and are there other experiments
potentially useful to us that will run only using triple axis gradients?
We are also looking at microprobes. How do the Bruker 2.5 mm probes
compare to, for example, the Nalorac probes? Thank you in advance for
your input.
Sincerely,
Brian
K. Brian Killday
Research Specialist
Division of Biomedical Marine Research
Harbor Branch Oceanographic Institution
5600 U. S. 1, North
Ft. Pierce, FL 34946
Phone: 561-465-2400 ext. 456
Fax: 561-461-2221
Email: killday@hboi.edu