I missed a word below: it is particularly the TCI Prodigy probe that I am interested in... do the cost savings make it a practical stand-in for a helium-cooled TCI probe when working with protein samples? Probe-swapping isn't an issue, as we deal pretty much only with biomolecular samples, and won't have any other probes.
Does anyone have experience with the triple-resonance TCI cryoprobe? We should be able to upgrade our old 500 console, and get a non-RT probe, but need to jusitfy what we absolutely cannot live without.
For protein applications, in particular triple-resonance backbone and sidechain assignment experiments, how does it compare to a helium-cooled cryoprobe? When you have a "real" sample--- some salt, some buffer, does it offer an improvement over RT probes? How much of a difference is there from a He cryoprobe? We're going to look into running some tests, if possible, but in the meantime thought I'd send the question out.
We had a cold probe on the 500 in the past, and it definitely made the instrument much more useful... it was varian vintage 2004 (I think it was a pretty good one... I stopped using it as it needed maintenance, and the magnet was moving to a temporary location lacking the infrastructure to re-install it).
Thanks very much for any input,
Tara
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Dr. Tara Sprules
QANUC
Quebec/Eastern Canada High Field NMR Facility
www.nmrlab.mcgill.ca
phone: (514) 398-1721
fax: (514) 398-8254
3420 University St., Rm 023
McGill University
Montreal, QC, H3A 2A7
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Received on Fri Jan 12 2018 - 10:05:22 MST