Hello,
I've been asked to post this to AMMRL. I would much appreciate you
forwarding the following information on to any potential candidates.
Interested parties should contact Professor Celia Schiffer.
Thank you.
Piotr
POSTDOCTORAL POSITION AVAILABLE
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Our laboratory studies changes in substrate specificity both in vivo and
in vitro correlated with drug resistance in HIV-1 protease using
biochemical and biophysical techniques. Research is in collaboration
with clinical and molecular virology as well as computational chemistry
groups. Techniques include protein crystallography, molecular biology,
enzyme kinetics, isothermal titration and differential scanning
calorimetry, molecular dynamics, genomic sequence analysis and NMR.
Candidates with a background in molecular dynamics of proteins
(experience with AMBER or GROMOS), enzyme kinetics, protein
crystallography or structural protein NMR (experience with Varian
INOVA600) are especially encouraged to apply. Opportunity to learn
protein expression, purification, crystallography and protein structural
analysis will exist as part of the position. Three separate
postdoctoral positions are currently open.
For further information please contact or to apply please send CV and
arrange for three letters of reference.
Celia Schiffer, Ph.D.
Associate Professor
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
364 Plantation Street, Rm 923
Worcester MA, 01605-2324
http://www.umassmed.edu/bmp/faculty/schiffer.cfm
(508) 856-8008
(508) 856-6464
Celia.Schiffer_at_umassmed.edu
Recent Publications:
Schiffer, C.A. and van Gunsteren, W.F., "Accessbility and order of water
sites in and around proteins: a crystallographic time-averaging study."
Proteins Vol. 36, 501-511 (1999).
Prabu-Jeybalan, M.M., Nalivaika, E., Schiffer, C.A. "How does a
symmetric dimer recognize an asymmetric substrate? The first complex of
HIV-1 protease bound to a substrate from gag-pol" J. Mol. Biol.
301(5):1207-20 (2000).
Scott, W.R.P., Schiffer, C.A. "Curling of Flap Tips in HIV-1 Protease as
a Mechanism for Substrate Entry and Tolerance of Drug Resistance."
Structure Vol 8, 1259-1265 (2000).
King, N., Melnick, L., Prabu-Jeybalan, M. Nalivaika, E., Yang, S-S.,
Gao, Y., Nie, X., Zepp, C., Heefner, D. Schiffer, C.A. "Lack of Synergy
for Inhibitors Targeting a Multi-drug-resistant HIV-1 Protease." Protein
Sci 2002 Feb;11(2):418-29 (2002)
Prabu-Jeybalan, M.M., Nalivaika, E., Schiffer, C.A. "Substrate shape
determines specificity of recognition for HIV-1 protease: Analysis of
crystal structures of six substrate complexes." Structure 10(3)
369-381(2002).
Pettit, S.C., Henderson, G.J., Schiffer, C.A., Swanstrom, R.
"Replacement of the P1 amino acid of Human Immunodeficiency Virus Type-1
Gag processing sites can inhibit or enhance the rate of cleavage by the
viral protease" J. Virology 76(20)10226-10233 (2002).
Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
"Viability of a drug-resistant HIV-1 protease variant: structural
insights for better anti-viral therapy." J. Virology 77(2):1306-15
(2003).
Kurt, N., Scott, W.R.P., Schiffer, C.A., Haliloglu, T. "Vibrational
dynamics of unliganded and substrate-bound HIV-1 protease: Analysis
with gaussian network model on variety of conformations from
crystallography and molecular dynamics simulation" in press Proteins.
(NOTE: Schiffer & Haliloglu are joint last/corresponding authors)
Wu, T.D., Schiffer, C.A., Gonzales, M., Kantor, R., Chou, S., Israelski,
D., Zolopa, A., Fessel, J., Shafer, R.W. "Mutation patterns and
structural correlates in HIV-1 Protease following varying degrees of
protease inhibitor treatment" in press J of Virology
Received on Wed Feb 05 2003 - 07:44:50 MST