posted on behalf of Matthias Buck, please distribute - Victor
http://nmr900.ca
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Case Medical School, Case Western Reserve University, Cleveland, Ohio
Postdoctoral position to study Protein-Protein Interactions and their role in Mechanisms of Signal Transduction using protein solution NMR and x-ray crystallography
How are signaling events transmitted from one protein to another? To answer this question we are looking to add a postdoctoral co-worker to our interdisciplinary team. Our interest is to understand protein-protein interactions, protein structure and dynamics in the context of cell signaling mechanisms, e.g. see our recent papers J.Biol.Chem. 284, 35962-72 (2009); J.Biol.Chem. 286, 26093-106 (2011); Structure 20, 41-55 (2012). The systems include several small GTPases and their interacting proteins, principally the cytoplasmic domains of plexins and of other receptors.
Research in protein biophysics/structural biology. We principally use solution NMR for protein structure determination, surface mapping and characterization of conformational change. The project may involve amide hydrogen exchange, NMR relaxation and molecular dynamics simulation as additional tools. NMR facilities at the Cleveland Center for Structural Biology consist of two 600MHz, an 800MHz and an 900MHz Bruker spectrometers all with cryoprobes. Apart from NMR, we employ other biophysical techniques including circular dichroism and fluorescence spectroscopy as well as isothermal titration calorimetry (ITC). Recently have started x-ray crystallography as a second major component to the laboratory (a Rigaku MicroMax-007 HF instrument with a 94x94mm CCD detector has recently been installed for crystal screening).
We are looking for a talented and motivated coworker, who aim to become independent researcher/project leader. Prior experience with protein NMR or x-ray crystallography is essential. The Buck laboratory provides a stimulating but friendly working environment - we are still relatively small & young, which has advantages. The Medical School of Case Western Reserve University is highly rated overall in the US (~ 16th in terms of NIH funding) and Cleveland is a pleasant but affordable place to live with excellent educational, medical and cultural institutions. Starting date, project details and salary are negotiable. Please send your resume, overview of your scientific interests and career goals as well as contact details of three referees able to provide references by e-mail to Matthias.Buck_at_case.edu
Matthias Buck, MA, DPhil
Associate Professor
Case Western Reserve University
Department of Physiology & Biophysics
School of Medicine, E607
10900 Euclid Avenue
Cleveland, Ohio, 44106-4970
Phone: 216-368-8651
Fax: 216-368-3952
E-mail: Matthias.Buck_at_case.edu
http://biophysics.case.edu/people/faculty/Matthias%20Buck
Received on Thu Sep 27 2012 - 12:40:22 MST