Hi Neil
Regarding the price of a probe - we recently requested a quote from Bruker for a 600MHz single-axis gradient QCI-F cryoprobe. We were expecting it to be around $150K, but the quote came back as $200K. The purchase has now been put on hold.
Brendan M. Duggan, PhD
NMR Facility Director and Associate Project Scientist
Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California at San Diego
9500 Gilman Drive, MC 0684
La Jolla CA 92093
office phone: (858) 534-8763
lab phone: (858) 822-7826
cell phone: (858) 692-2298
email: bmduggan_at_ucsd.edu
http://sopnmr.ucsd.edu
http://sopnmr.blogspot.com
________________________________
From: Jacobsen, Neil E - (neil) [neil_at_email.arizona.edu]
Sent: Tuesday, November 10, 2015 11:52 AM
To: ammrl_at_ammrl.org
Cc: Jon Njardarson
Subject: AMMRL: 19F decoupled 13C spectra
As incorporation of fluorine into organic molecules is becoming a pharma fad, we are getting more interest in 19F NMR experiments. The biggest practical problem is how to get a 13C spectrum of a fluorinated compound without using a very large sample concentration. I would like to have a way to 19F decouple during the 13C FID, but then I would lose the 1H decoupling. I’m wondering how people are dealing with this problem, if there are any interesting experiments or methods. Of course, hardware is always a limitation. Bruker said they could modify our 400 probe to “widen” the 1H coil to include 19F, with a small sacrifice of 1H sensitivity. One method I can imagine is to record two 13C spectra: one 19F deoupled and one 1H decoupled, and then combine the data somehow.
I just got a quote from Bruker for a 19F probe for our 600, the price was about 2X what I expected for a typical probe. I’m wondering what people consider the price of a 600 MHz single-axis gradient probe to be these days.
Any suggestions or anecdotes will be appreciated.
Neil
Received on Thu Nov 12 2015 - 07:56:39 MST