Hi Ammrlers,
I have forwarded here the announcement for our next IVAN Round-table Workshop
on Thursday March 30th at Noon EDT. Roberto Gil of Carnegie Mellon University will
lead a panel to discuss the applications of NMR in anisotropic media for structural
analysis of small molecules – that is RDC’s, RCSA’s and RQC’s. See you there!
Also, don’t forget the upcoming IVAN user meeting, Again Live from Asilomar. The
date is Saturday April 15th. Our Agenda is set and it will be out shortly.
In addition, the nomination period for the IVAN Founder’s Award is still open. The
official deadline is next week – March 10th. I you have someone in mind – contact
me or Krish by email – even a little after the 10th. We on the committee will help
you get the nomination materials put together. The award is $2500! (and a MOVA globe).
We look for individuals who have uniquely served the NMR community to foster education
and communication.
Thanks,
Dave
David M. Rice Ph.D.
Director ORED NMR Facility
376 Science and Engineering 2
University of California, Merced
5200 N. Lake Road, Merced CA 95343
Office: 1-209-228-4606
NMR Lab 1-209-228-2508
Mobile: 1-650-267-0593
Email: drice2_at_ucmerced.edu<mailto:drice2_at_ucmerced.edu>
From: IVAN Users Group <ivaninfo_at_ivanmr.com>
Reply-To: IVAN Users Group <ivaninfo_at_ivanmr.com>
Date: Friday, March 3, 2023 at 3:27 AM
To: Dave Rice <drice2_at_ucmerced.edu>
Subject: IVAN Anisotropic Interactions in NMR Workshop March 30, 2023
[
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Dear David,
Our Next IVAN Research Round-table Workshop on
Thursday March 30, 2023 at 12:00 PM ET.
“Anisotropic Interactions in NMR (RQCs, RDCs, RCSAS) and their application to the analysis of small molecules”
Roberto Gil, Carnegie Mellon University will lead the panel
The topic of our March round-table workshop (Thursday March 30, 2023 _at_ 12:00 PM ET USA) will be a discussion of Anisotropic Interactions in NMR (RQCs, RDCs, RCSAS) and their application to the analysis of small molecules. Roberto Gil of Carnegie Mellon University will lead the panel that includes Han Sun -Leibniz Research Institute for Molecular Pharmacology, Berlin, Germany, Philippe Lesot - University of Paris-Saclay, Orsay, France, and Robert T. Williamson Univ of North Carolina Wilmington, USA.
The configurational (3D structure) and conformational analysis of small molecule by NMR spectroscopy has been historically performed using NMR parameters such as chemical shift, J-coupling constants and the nuclear Overhauser effect (NOE). However, there are cases in which the use of these three NMR parameters is not enough to lead to a unique solution to the structural problem. This limitation can be lifted by the application of anisotropic NMR parameters such as Residual Dipolar Couplings (RDCs), Residual Chemical Shift Anisotropies (RCSAs) and Residual Quadrupolar Couplings (RQCs). RDCs, RCSAs and RQCs are not directly observed in a solution that solely uses NMR solvents, but they are observable in the presence of alignment media such as physically strained (compressed or stretched) polymers gels or lyotropic liquid crystalline solutions (LLC phases) made with homopolypeptides, polyacetylenes, graphene oxide derivatives and self-assembling peptides. NMR in anisotropic media is a game changer in 3D structure elucidation of small molecules since anisotropic NMR parameters can correlate the relative configuration of remotely located stereocenters regardless of the distance between them. Even if the structural problem can be unambiguously solved using isotropic NMR parameters, the complementary use of anisotropic NMR parameters represents an orthogonal way of 3D structure confirmation. We will a panel discussion of practical applications of NMR in anisotropic media to the structural analysis of small molecule. The members of the panel will show applications to their everyday structural problems.
As always, we encourage you to visit the IVAN web page
http://ivanmr.com<
https://ivanmr.us14.list-manage.com/track/click?u=6daa8e546cd13312e63671ad7&id=adc0607443&e=f26c80bd0c>! You will find the links to past workshops and our recent IVAN ENC meeting on You Tube as well as the complete schedule of past and upcoming workshops.
Click on the link below to register and receive the meeting link!
You are invited to a Zoom meeting.
When: March 30, 2023 at 12:00 Noon Eastern Time (US and Canada)
Register in advance for this meeting:
https://us02web.zoom.us/meeting/register/tZErd-GgpjstGNeSPHDfdYjD3U3iYUqYoSQa<
https://ivanmr.us14.list-manage.com/track/click?u=6daa8e546cd13312e63671ad7&id=33782eb8e0&e=f26c80bd0c>
See You on March 30, 2023!
Thanks for Your support!
The 2022 Executive Committe: Jon Webb (CEO of MRR and VP of Q One Americas), Dan Iverson, Krish Krishnamurthy, Dave Rice, Eric Schatzlein (MRR)
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Received on Fri Mar 03 2023 - 09:09:47 MST
