Re: AMMRL: Impurity in library compounds

From: Zhang, Weixing <Weixing.Zhang_at_STJUDE.ORG>
Date: Thu, 20 Jun 2019 00:14:30 +0000

Exchangeable N-H and O-H protons also show positive peak in Water-LOGSY.

If these signals are from N-H or O-H, what molecule is it?


Thanks,

Weixing


________________________________
From: Zhang, Weixing
Sent: Wednesday, June 19, 2019 2:38 PM
To: ammrl_at_ammrl.org
Subject: Impurity in library compounds


Hello All,



When we are analyzing our library compounds, we found an unknown impurity in many compounds.

The impurity has a splitting of 52 Hz and 9.4 Hz as shown in the (500 MHz NMR spectrum).

It aggregates in solution because Water-LOGSY shows positive signal.



Your suggestion to identify this impurity is appreciated!



Thanks,

Weixing



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Received on Wed Jun 19 2019 - 14:15:11 MST