Dear Yufeng,
>I'd wonder anyone would tell me where I can find the normal ratios of
>NAA/CHO, NAA/Cr or NAA/(CHO+Cr) in brain hippocampus cells, where NAA
>stands for N-acetyl-aspartate, CHO stands for choline, Cr stands for
>creatine-phophocreatine.
You need to specify if the ratios are 'plain spectral integral ratios',
'saturation corrected ratios', or 'absolute concentration ratios', as
well as the specific acquisition conditions (pulse sequence, TE, TR,
etc). Would you prefer to average tissue concentrations, or the acqueous
concentrations (70-80% water in the brain)?
>I think these values should appear in the textbooks but since I formerly
>focus on protein NMR, I'm not familiar with the the MRS of these
>metabolite.
A good book with a lot of info on neuro-NMR-spectroscopy is Else Rubaeck
Danielsen/Brian Ross: Magnetic resonance spectroscopy diagnosis of
neurological diseases. (Publisher: Marcel Dekker). Jens Frahms group has
has done important basic work on the normal tissue concentrations, as has
Gunther Helms (now at Tuebingen, Germany).
BTW, I don't have any specific values for hippocampus. You will probably
have to establish your own local normal values, obtained from a group of
matched, healthy volunteers.
73, Peter
_at_ _at_
..
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Received on Thu Jan 09 2003 - 09:40:49 MST