Dr. Arun Alphonse Ignatius has an opening for a NMR focussed PostDoc position in his group at Pfizer in St. Louis and asked me to spread the word to anybody interested. Please feel free to pass this along to your friends or others in the field who might be interested.
Markus
All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. As we
continue to develop healthcare products and expand our business globally, we are consistently looking for new
talent. We are currently seeking highly qualified candidates to fill this position:
Postdoctoral Fellow, Antibody Structure and Dynamics via NMR
United States-Missouri-Saint Louis
The postdoctoral fellow will advance our understanding of solution behavior of antibodies (protein-protein selfassociation)
that leads to protein aggregation and viscosity in highly concentrated biologic drug solutions. The
primary responsibility of the candidate will be to implement modern NMR techniques and further develop highresolution
NMR spectroscopy toolbox to investigate large proteins. The individual will develop structural models using
sparse NMR data and molecular modeling and help improve the design and/or selection of monoclonal antibody
candidates optimal for clinical development. This work will involve collaboration with protein expression/purification
scientists & high-field NMR instrumentation facilities.
A Ph.D. in Biophysics, Biochemistry, Chemical Engineering or related fields is required with 1 - 2 years of postdoctoral
research experience preferred.
• Expertise in modern NMR pulse programs and processing tools with direct experience in large proteins is
desirable.
• Expertise in structure computation using sparse NMR data (RDC/PCS/PRE) and restrained molecular dynamics
tools
• Experience in isotopic labeling of proteins (preferably mammalian cells) and protein purification
• Advanced understanding of antibody structure-function.
• Experience in probing protein-protein interactions in relation to aggregation and viscosity.
• Experience in biophysical characterization of proteins.
The successful candidate shall be highly motivated, hardworking, and intellectually productive team player with
proven scientific research productivity as demonstrated by publications in high impact journals. Fluency in oral and
written English is required. Good inter-personal and communication skills are required.
For more information and to apply please go to www.pfizercareers.com<
http://www.pfizercareers.com> and search for Job ID 1023912.
Received on Thu Dec 10 2015 - 11:54:43 MST