Folks,
Occassionally, we would like to do a 'quick & dirty' estimate of an
impurity in an NMR spectrum. For example, we may want to know if there is
1-2% acetone in our sample. I would like to know what is a proper
calculation for determining the percent impurity in a sample. I've seen
one calculation which involves dividing the area of the impurity peak by
the number of protons and likewise dividing the area under a peak in the
sample by the number of protons representing that peak. Then multiply
each of these by their respective Formula Weights and use these values to
calculate a wt percent. Does this make sense?
Thanks in advance for your comments.
Ben
Benjamin Banks, Ph.D.
Senior Analytical Chemist
Pharmacore/TransTech Pharma
4180 Mendenhall Oaks Pkwy
High Point, NC 27265
(336) 841-5250 ext 127 phone
(336) 841-5251 FAX
bbanks_at_pharmacore.com
www.pharmacore.com
www.ttpharma.com
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Received on Wed Aug 06 2008 - 07:31:18 MST